Why A4LI?


The Alliance for Longevity Initiatives (A4LI) is an independent 501(c)(4) nonprofit organization, with the mission to advance legislation and policies that aim to increase healthy human lifespan, with a focus on accelerating equitable access to next-generation therapies.

Problem #1: Aging Kills and Contributes to Chronic Diseases

Aging is the leading risk factor for many chronic diseases that account for the majority of morbidity and mortality worldwide. As we age, our bodies undergo a gradual decline in function, increasing our susceptibility to various age-related conditions, such as cardiovascular diseases, cancers, respiratory diseases, and diabetes.

1.) Cardiovascular diseases: These account for 31% of all global deaths, with approximately 17.9 million fatalities each year. Aging plays a significant role in the development and progression of these diseases.

2.) Cancer: 60% of people diagnosed with cancer are aged 65 or older, highlighting the impact of aging on cancer development and progression.

3.) Neurodegenerative diseases: Conditions like Alzheimer's and other forms of dementia become increasingly prevalent with age, affecting around 50 million people worldwide and expected to triple by 2050 due to an aging global population.

Understanding and targeting the nine hallmarks of aging can help develop interventions that slow or reverse aging, ultimately reducing the burden of age-related diseases and extending healthy life expectancy.

Problem #2: The Financial Burden of Aging and Age-Related Diseases

Aging and age-related diseases impose a substantial financial burden on individuals, families, healthcare systems, and national economies. As the global population ages, these costs are expected to rise dramatically, straining resources and affecting economic growth.

1.) Direct medical costs: The treatment of chronic diseases associated with aging leads to significant healthcare expenditures. For example, the annual cost of treating Alzheimer's and other dementias in the United States is projected to reach $355 billion by 2030.

2.) Indirect costs: Age-related diseases often result in reduced productivity, leading to substantial economic losses. The economic burden of dementia in the United States was estimated at $277 billion in 2018, with $123 billion attributed to lost productivity for both patients and caregivers.

3.) Caregiving expenses: As individuals age and develop chronic health conditions, they often require assistance with daily activities, leading to increased caregiving costs. In 2017, approximately 41 million family caregivers in the United States provided an estimated 34 billion hours of care, equivalent to $470 billion in economic value.

The Longevity Dividend: Reaping the Economic Benefits

Investing in research and interventions to slow the aging process and extend healthy life expectancy can yield significant economic benefits, both by reducing healthcare costs associated with age-related diseases and by increasing productivity.

1.) Reduced healthcare costs: By delaying or preventing age-related diseases and disabilities, we can reduce healthcare expenditures, easing the financial burden on individuals, families, and governments.

2.) Increased productivity: A healthier and more active aging population can contribute to the workforce for a longer period, boosting economic growth and reducing the strain on social welfare programs.

3.) Economic value: According to an economic analysis by Andrew Scott, extending a population's healthspan by just one year could result in an estimated economic value of $38 trillion.

The Solution: The Alliance for Longevity Initiatives

A4LI is the first and only 501(c)(4) nonprofit organization dedicated to creating social and political action around the issues of combating age-related chronic conditions and increasing our number of healthy, disease-free years. Supporting A4LI offers a unique opportunity to contribute to a brighter, healthier future for all.

1.) Collaboration: A4LI works with renowned professionals in the geroscience and regenerative medicine fields to drive awareness of the potential of longevity research among US government officials.

2.) Advocacy: A4LI is committed to promoting national-level support for the extension of healthy lifespans through political reform, increased funding, and streamlined regulatory pathways.

3.) Education and Outreach: A4LI raises awareness of the economic, social, and personal benefits of extending healthspan through media, events, and direct outreach, helping to build public support and encourage policymakers to prioritize investments in aging research.

4.) Equity and Accessibility: A4LI emphasizes the importance of ensuring equitable access to next-generation therapies, advocating for policies that foster affordability and inclusivity, so that the benefits of longevity research can be enjoyed by all, regardless of socio-economic status.

By supporting the Alliance for Longevity Initiatives, you can help create lasting change and redefine the boundaries of human health and longevity. With your support, we can build a healthier, more prosperous future for generations to come.